SFC Fluidics® Partners with PercuSense and Diabeloop to Improve Diabetes Care

JDRF funding will advance integration of an insulin delivery pump with a continuous glucose monitor and a control algorithm into a single pod artificial pancreas.

FAYETTEVILLE, AR – SFC Fluidics, Inc. (SFC) has partnered with two companies, Diabeloop SA and PercuSense, Inc., as part of the Industry Development and Discovery Partnership that was awarded to SFC Fluidics in 2018 by JDRF.

JDRF is sponsoring this project for the development of a single integrated pod artificial pancreas (AP) system for people with type 1 diabetes (T1D). By accelerating the development of a next-generation miniaturized and user-friendly AP system, JDRF will further its goal of reducing the daily burden for people with T1D while improving their overall health outcomes. State-of-the-art AP systems such as this are especially important for children and young adults with T1D who want to achieve better outcomes while living as normal a lifestyle as possible.

The AP system currently under development will consist of an insulin pump and continuous glucose monitor (CGM) that are housed in a single on-body pod. The pod will be controlled wirelessly via a proprietary closed-loop algorithm running on a handheld device. For the past year, SFC has focused on the optimization of its proprietary insulin pumping technology and platform. The key features of SFC’s insulin pump include best-in-class accuracy and precision at very small dose volumes, a two-valve safety system, and a dispense confirmation sensor. PercuSense will contribute its cutting edge CGM that features calibration-free glucose detection. PercuSense is dedicated to the development of a simple inserter and low-cost manufacturing. Diabeloop, a pioneer in diabetes management, will contribute a machine-learning control algorithm to automate insulin delivery.

“We are very excited to work with excellent technical and business partners such as PercuSense and Diabeloop. We look forward to the challenge and opportunity of creating a fully automated, miniaturized, integrated AP system for patients with diabetes. Our system will simplify and improve efforts to enhance glycemic control and free people with T1D to lead a more active and carefree lifestyle,” said Tony Cruz, CEO of SFC Fluidics, “SFC Fluidics is grateful for the opportunity granted by this collaborative funding from JDRF.”

“Our mission at Diabeloop is to bring innovation to families affected by diabetes. Therefore, we are delighted to be part of this highly promising technological project and equally honored by JRDF support,” commented Marc Julien, co-CEO of Diabeloop.

“We are very happy to see SFC making progress and establishing the partnerships necessary to make these next-gen automated insulin delivery systems a reality. By teaming up with leaders in the fields of continuous glucose sensing and insulin delivery algorithms such as PercuSense and Diabeloop, SFC is laying a solid foundation to maximize their chances of success and ensure high performance of these products,” said Jaime Giraldo, Scientist at JDRF.

About SFC Fluidics, Inc.      
SFC Fluidics, Inc. has a mission to advance healthcare and improve quality of life through our enabling microfluidic technologies. The company’s vision is to become a recognized global leader in drug delivery, with a focus on insulin, where our unique product lines improve lifestyle and affordability. SFC Fluidics® is a VIC Technology Venture Development™ portfolio company. For more information, please visit sfc-fluidics.com or follow us on Twitter: @sfcfluidics.

About Diabeloop SA
Diabeloop is a young company developing disruptive technological innovations to automate the treatment of T1D. Created in 2015 in Grenoble by Erik Huneker and Dr. Charpentier, Diabeloop and CEA-Leti work within a joint research laboratory to accelerate product development. The company is co-managed by Marc Julien and Erik Huneker and employs approximately 50 people. Diabeloop received first round funding of 13.5 million Euros in 2017 and second round funding is ongoing. For more information, please visit diabeloop.com.

About PercuSense
PercuSense is focused on developing next generation continuous sensing platforms that enable prediction, intervention, and prevention in chronic diseases and acute conditions including diabetes management and in-hospital monitoring. PercuSense’s unique technology enables low cost, glucose plus multi-analyte sensing to bring affordable and actionable continuous monitoring to the market while greatly improving usability through its integration into a single sensing and delivery site. For more information, please visit percusense.com.

About JDRF
JDRF is the leading international nonprofit fighting to cure T1D while also helping those with T1D live healthy lives today. Supported by hundreds of thousands of donors, JDRF raises, invests and drives more funds to T1D research than any organization in the world. As a result, JDRF has played a key role in major T1D advances – drug, device, cell research – that have improved lives and brought us closer to our ultimate goal of a cure. JDRF is mission-driven and serves as an aggressive advocate and educational support for the T1D community. JDRF has staff and volunteers across the United States, has five international affiliates, funds research in more than 20 countries and supports insulin-aid efforts in the U.S. and around the world. Visit jdrf.org to learn more.


SFC Fluidics, Inc. Receives SBIR Phase II Funding to Develop a Dual Hormone Patch Pump for Patients with Diabetes

Miniaturized system will allow accurate insulin and glucagon dosing in a discreet, low profile patch pump for patients with Type 1 diabetes.

FAYETTEVILLE, Ark. – September 20th, 2018 – SFC Fluidics® is pleased to announce that it has been awarded a $1.4 million grant to support development of a dual hormone patch pump for patients with diabetes.

There are 4 million insulin-dependent Type 1 diabetics worldwide and this number is expected to increase over time. The challenges of maintaining proper glycemic control are particularly difficult for young patients who understandably dislike the multiple needle sticks required for measuring blood glucose levels and delivering the appropriate doses of insulin or glucagon. SFC’s proposed patch pump system will have the necessary safety features and dose accuracy to allow automated insulin and glucagon dosing to achieve fine-tuned glycemic control in patients with Type 1 diabetes.

SFC Fluidics’ proprietary ePump® system can control the delivery of both insulin and glucagon in a discreet patch pump that is the same size as the insulin-only patch pumps currently on the market. A second proprietary feature of the proposed system is a flow confirmation sensor that determines whether dose administration has occurred as expected in real-time. This sensor will quickly alert to any problems within the patch pump such as occlusions, leaks, depleted drug supply, accidental misloading, and any mechanical/electrical failure. According to Dr. Forrest Payne, the Principal Investigator on the project, “The suite of patents and patent applications that covers SFC Fluidics’ system - from the pump to the valves to the sensors - will allow for development of a next generation dual-hormone patch pump that combines safety, convenience and small size with excellent accuracy and precision.”

“We think the proposed system will be especially attractive to adolescents with Type 1 diabetes and will serve the broader diabetic community as well. What’s more, we see the dual hormone drug delivery system as a vital part of a future state-of-the-art artificial pancreas,” remarked Greg Lamps, SFC’s Vice President of Product Realization.

SFC Fluidics, Inc. has a mission to advance healthcare and improve quality of life through our enabling microfluidic technologies. The company’s vision is to become a recognized global leader in the drug delivery and health monitoring markets where our unique product lines improve lifestyle and affordability. SFC Fluidics® is a VIC Technology Venture Development™ portfolio company.

The described research is supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, under Award Number 2R44DK110972-02. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Contact: Ashley Shemain

Vice President, Marketing & Business Development

479.527.6810

ashemain@sfcfluidics.com

SFC Fluidics, Inc. Announces Partnership with JDRF to Develop Patch Pump with Open-Protocol Communication

FAYETTEVILLE, AR – July 30, 2018 – SFC Fluidics, Inc. (SFC), a medical technology company, today announced a new Industry Discovery and Development Partnership supported by JDRF, the leading global organization funding type 1 diabetes (T1D) research.

In line with JDRF’s goal to discover, develop, and deliver advances that reduce the burden of T1D and expand access to and adoption of automated insulin delivery (AID) technologies, JDRF will provide funding to SFC for the development of an insulin patch pump with open-protocol communication capabilities. JDRF launched its Open-Protocol Automated Insulin Delivery (AID) Systems Initiative in 2017 with the goal to work with key stakeholders to understand the regulatory and liability implications of an “open-protocol” AID ecosystem – in which AID components may be seamlessly and safely interoperable – and moreover to accelerate the delivery of such components to market. The development and delivery to market of a fully interoperable, open-protocol insulin pump is the goal of this JDRF-SFC partnership.

Insulin-dependent diabetes impacts more than six million Americans, the vast majority of whom are not reaching clinical targets for optimal glucose levels. Insulin is a life-saving drug but needs to be dosed accurately and safely to avoid serious adverse events.

The two-year funding commitment from JDRF enables SFC to accelerate the development and regulatory submission of an open-protocol patch pump system that enable seamless, secure connectivity with other devices (e.g., by using Bluetooth technology) such as interoperable continuous glucose monitors (CGMs) and third-party AID algorithms. Such algorithms may include solutions developed in recent years by the do-it-yourself (DIY) community, a following which is steadily gaining traction.

The foundation of SFC’s insulin delivery technology, covered by several issued and applied-for patents, is its inherently small size and capability to deliver highly accurate doses of insulin. SFC will develop a fully functional patch pump that will operate on its own platform as well as publish its communication protocol so that approved devices can communicate with the patch pump.  

"There is a passionate group of people behind a patient-driven ecosystem, using do-it-yourself (DIY) approaches to develop solutions to meet their needs. We believe SFC’s unique pumping technology will provide new options for them to live the lifestyle that suits them the best," said Anthony Cruz, CEO of SFC Fluidics. "With our partnership with JDRF, we will bring new and innovative solutions to the diabetes community."

”We are excited to support SFC in its open-protocol pump development as a key step toward the realization of our goal of an open-protocol AID ecosystem,” said Daniel Finan, JDRF Research Director. “We are hopeful that solutions such as this will greatly expand choice in the marketplace, increase adoption of advanced, life-improving technologies among people with T1D, and accelerate the cadence of innovation in these treatment options.”

About JDRF
JDRF is the leading global organization funding type 1 diabetes (T1D) research. Our mission is to accelerate life-changing breakthroughs to cure, prevent and treat T1D and its complications. To accomplish this, JDRF has invested more than $2 billion in research funding since our inception. We are an organization built on a grassroots model of people connecting in their local communities, collaborating regionally for efficiency and broader fundraising impact, and uniting on a national stage to pool resources, passion, and energy. We collaborate with academic institutions, policymakers, and corporate and industry partners to develop and deliver a pipeline of innovative therapies to people living with T1D. Our staff and volunteers throughout the United States and our six international affiliates are dedicated to advocacy, community engagement and our vision of a world without T1D. For more information, please visit jdrf.org or follow us on Twitter: @JDRF.

About SFC Fluidics, Inc.
SFC Fluidics, Inc. has a mission to advance healthcare and improve quality of life through our enabling microfluidic technologies. The company’s vision is to become a recognized global leader in drug delivery, with a focus on insulin, and health monitoring markets where our unique product lines improve lifestyle and affordability. SFC Fluidics® is a VIC Technology Venture Development™ portfolio company. For more information, please visit sfc-fluidics.com or follow us on Twitter: @sfcfluidics.

Media Contacts:

Ashley Shemain
VP, Marketing & Business Development
ashemain@sfcfluidics.com
479-527-6810, Ext 7004

Ayana Young
JDRF Manager, Public Relations & Communications
media@jdrf.org 
212-859-7895

SFC Fluidics, Inc. Announces Partnership with JDRF to Develop Pod Device for Automated Insulin Delivery

FAYETTEVILLE, AR – January 22, 2018 – SFC Fluidics, Inc. (SFC), a medical technology company, today announced a new Industry Development and Discovery Partnership supported by JDRF, the leading global organization funding type 1 diabetes (T1D) research.

JDRF will provide funding to SFC for the development of a single pod Automated Insulin Delivery (AID) device and thus, expand future therapy options for people with T1D. JDRF launched its Artificial Pancreas Project in 2006 to accelerate the development of commercially available closed-loop systems. Since then, significant progress has been made and several automated insulin delivery systems have progressed to human clinical trials, with one currently on the market.

While there are several products in development, surveys indicate the size and form factor of these systems play a major role in their adoption. This factor is especially compounded in children, where skin “real estate” is at a premium. One of JDRF’s goals is to reduce the daily burden for people with diabetes while improving their overall health.

Insulin-dependent diabetes impacts more than six million Americans, the vast majority of whom are not reaching clinical targets for optimal glucose levels. Insulin is a life-saving drug but needs to be dosed accurately and safely to avoid serious adverse events.

The two-year funding commitment from JDRF allows SFC to pursue the development of a next-generation AID system that reduces the on-body burden by integrating all components into one disposable, miniaturized device that delivers insulin.

The foundation of SFC’s insulin delivery technology, covered by several issued and applied-for patents, is inherently small in size and has the potential to deliver highly accurate doses of insulin. SFC will integrate a continuous glucose monitor (CGM) and an algorithm into a single pod that can be disposed of every three days. 

"There has been tremendous progress in the development of CGM devices and closed loop algorithms. However, the integration of a pump, a CGM and an algorithm into a single, convenient pod that reduces the on-body burden for the patient has not been successfully addressed. We believe SFC’s unique pumping technology allows for an integrated AID system that will offer people with T1D an improved lifestyle," said Anthony Cruz, CEO of SFC Fluidics. "With our partnership with JDRF, we will bring new and innovative solutions to the diabetes community."

”We are proud to be supporting SFC as part of our effort to advance the development of next-generation automated insulin delivery systems, to offer greater choice to people with T1D, and to lessen the burden of living with this disease while we search for a cure,” said Jaime Giraldo, JDRF Program Scientist, Research. “By funding the development of miniaturized devices that are easier to
wear and include algorithms for automation, it is our goal to make diabetes therapies less intrusive for those who must use them daily to live.”

About JDRF
JDRF is the leading global organization funding type 1 diabetes (T1D) research. Our mission is to accelerate life-changing breakthroughs to cure, prevent and treat T1D and its complications. To accomplish this, JDRF has invested more than $2 billion in research funding since our inception. We are an organization built on a grassroots model of people connecting in their local communities, collaborating regionally for efficiency and broader fundraising impact, and uniting on a national stage to pool resources, passion, and energy. We collaborate with academic institutions, policymakers, and corporate and industry partners to develop and deliver a pipeline of innovative therapies to people living with T1D. Our staff and volunteers throughout the United States and our six international affiliates are dedicated to advocacy, community engagement and our vision of a world without T1D. For more information, please visit jdrf.org or follow us on Twitter: @JDRF.

About SFC Fluidics, Inc.

SFC Fluidics, Inc. has a mission to advance healthcare and improve quality of life through our enabling microfluidic technologies. The company’s vision is to become a recognized global leader in drug delivery, with a focus on insulin, and health monitoring markets where our unique product lines improve lifestyle and affordability. SFC Fluidics® is a VIC Technology Venture Development™ portfolio company. For more information, please visit sfc-fluidics.com or follow us on Twitter: @sfcfluidics.
 

Media Contacts:

Ashley Shemain
VP, Marketing & Business Development
ashemain@sfcfluidics.com
479-527-6810, Ext 7004

Kristy Evans
JDRF Manager, Public Relations & Communications
kevans@jdrf.org
212-859-7877

SFC Fluidics, Inc. Receives SBIR Phase II Funding for Development of an Implantable Drug Delivery Device

The Min-ePump™, a miniaturized, implantable drug delivery device, will allow for on demand delivery of drugs and therapeutics.

FAYETTEVILLE, Ark. – August 24, 2017 – SFC Fluidics® is very pleased to announce it has received $1.5 million Phase II Small Business Innovation Research funding from the National Institutes of Health for the development of an implantable, wirelessly controlled, rapid dosing drug delivery system for small animal research. The Min-ePump™ implantable drug delivery pump will allow real-time, remote controlled delivery of drugs and therapeutics to animal models for addiction and behavior research studies.  This system will allow for improved testing methods, as currently animals are required to be tethered to a pump and tested in isolation.


Key research areas that can benefit from untethered animal behavior models include substance abuse, mood disorders, schizophrenia, choice behavior, sleep behavior, stimulus response, relapse, anxiety, avoidance, PTSD, chronic stress, aggressive behavior, cognition, depression, Alzheimer’s disease, Parkinson’s disease, aging disorders and management of chronic pain in humans. Additionally, the Min ePump™ will provide tremendous advantages for the development of a simple patch pump and artificial pancreas for people with diabetes. This technology will allow for miniaturization that will offer people with diabetes a new level of convenience and discretion to manage their diabetes.

SFC Fluidics, Inc. has a mission to advance healthcare and improve quality of life through our enabling microfluidic technologies. The company’s vision is to become a recognized global leader in the drug delivery and health monitoring markets where our unique product lines improve lifestyle and affordability. SFC Fluidics® is a VIC Technology Venture Development™ portfolio company.
Research reported in this release was supported by The National Institute of Drug Abuse of the National Institutes of Health under grant number [2R44DA041173-02]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Contact Author
ASHLEY SHEMAIN, VP OF MARKETING & BUSINESS DEVELOPMENT
SFC Fluidics, Inc. 
(678) 601 5370